Life sciences news: COVID-19 shot clinical data, Bill Gates on preventing the next pandemic


A COVID-19 vaccine designed and developed by Univ. of Washington researchers is studded with a key portion of a COVID-19 viral protein (in crimson). (UW Institute for Protein Design / Ian Haydon)

The week in life sciences within the Pacific Northwest began with disappointing information for Eliem Therapeutics. Its lead compound failed to indicate profit in a scientific trial for diabetic neuropathic ache, sending its inventory plummeting.

However the Seattle-based firm has some extra candidates within the wings. “We proceed to be excited concerning the potential of our pipeline of drug candidates in a number of neuronal excitability issues,” stated CEO Bob Azelby in a press release.

The week ended with constructive section 3 scientific information for a COVID-19 vaccine developed by College of Washington researchers, poised for distribution in South Korea. Learn on for this and different information from the Pacific Northwest.

Eliem Therapeutics shares sink greater than 50% after lead program fails to indicate profit in clinic

Research on respiratory infections, sort 1 diabetes, boosted with $17M to Benaroya Analysis Institute

Funding agency presents to purchase Vancouver, B.C.-based biotech Zymeworks for $733M in money

New members of the American Academy of Arts and Sciences, from left: Harmit Malik, Fred Hutch; Caroline (Carrie) Harwood, UW; Rachel Klevit, UW; Steven Henikoff, Fred Hutch. (UW and Fred Hutch Photographs)

UW COVID-19 vaccine:

  • The outcomes are in from a section 3 trial of a COVID-19 vaccine developed by UW researchers. South Korea-based SK Bioscience, which led the trial, reported that the shot was secure and yielded a stronger antibody response than the Oxford/AstraZeneca vaccine; T cell responses had been related or increased. The South Korean authorities intends to buy 10 million doses, in anticipation of regulatory approval there. The shot is easy to fabricate and steady with out deep freezing, situating it for broad distribution. The UW is licensing the tech royalty-free via the pandemic.

Digital well being and units:

  • Digital Sq., a bunch with Seattle nonprofit PATH, awarded $800,000 to 12 tasks “to enhance well being outcomes and assist shut the well being fairness hole around the globe.” Awardees embrace the UW Scientific Informatics Group, and funders embrace the Invoice & Melinda Gates Basis. Amazon Net Providers will present cloud computing credit as a part of its $40 million program to scale back inequities in healthcare.
  • Kestra Medical Applied sciences revealed findings on its wearable defibrillator to scale back sudden cardiac arrests. The machine, which gained FDA approval final summer time, confirmed a low fee of false alarms in the examine, led by UW Medication doctor Jeanne Poole. The Kirkland, Wash. startup additionally took house third place an annual commerce group competitors for medical units, within the cardiovascular class.

Research:

  • Fred Hutch researchers led a examine exhibiting that sure gene adjustments in cells of the esophagus are related to development to most cancers years later. The adjustments contain disruption in each chromosomal copies of a basic cancer-associated gene, TP53. The findings might result in checks to assist classify a affected person’s danger.
  • A new examine of digital well being information assesses which components might predict extreme sickness in hospitalized COVID-19 sufferers. Lab checks, important indicators and the necessity for supplemental oxygen had been extra necessary than components like continual situations or physique mass index, difficult present considering. The analysis was led by the Institute for Techniques Biology and included researchers at Swedish Windfall and different establishments.
  • A mannequin of COVID-19 transmission in jails assesses the consequences of assorted interventions on incarcerated folks and the broader neighborhood. “Working in a business-as-usual manner leads to substantial, speedy, and ongoing lack of life,” concluded the examine. First creator is Washington State College epidemiologist Eric Lofgren.

Tendencies and TED talks:

  • Invoice Gates wrote an editorial within the Wall Road Journal outlining easy methods to stop the following pandemic, following a latest TED speak on the topic. He suggests constructing a “World Epidemic Response and Mobilization” group, additionally a topic in his upcoming e book.
  • An essay by Seattle biotech researcher Jocelynn Pearl, “A information to decentralized biotech,” examines tendencies equivalent to distant work and the expansion of startups with operations in a couple of location.

Tech Strikes:

Actual Property:

  • Biotech-focused developer BioMed Realty purchased a 156,000 sq. foot constructing, at present leased by Meta, in Seattle’s South Lake Union neighborhood. The constructing is “lab succesful,” in keeping with a press launch from the developer, which didn’t present details about its plans. The acquisition comes on the heels of a 1.65 acre buy close by by the corporate and brings its whole workplace and lab house within the metropolis to 1.4 million sq. ft.





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